Interaction Of Inflammatory Parameters And Thiol/Disulfide System Of Antioxidant Protection In Chronic Obstructive Pulmonary Disease

Introduction — Increased incidence and prevalence of chronic obstructive pulmonary disease (COPD) provides rationale for describing the progression mechanism, considering interaction key participants this process. The objective our study was to establish dysfunction parameters thiol/disulfide system components adaptive immunity unit in patients with stable (COPD). Material Methods We examined COPD moderate (62 subjects) or severe (50 grades. control group included 32 subjects. Prooxidant antioxidant markers oxidative stress were investigated ELISA. determined cytokine levels blood plasma number T helper cells expressing IL-6R flow cytometry (BD FACSCanto II, USA). Correlation pleiads sensu Terentiev employed visualize data. Results Changes both status subjects varying severity grades implied systemic inflammation conditions uncontrolled activation rather than just a shift peroxide balance an increase oxygen metabolites. Conclusion Accumulation biomolecule peroxidation products, imbalance prooxidant-antioxidant system, change pathogenetic mechanism could lead aggravated course bronchopulmonary pathology.